Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

Book Details

  • Published: 01 August 2017
  • ISBN: 978-1-118-91669-8
  • Author: Ayman F. El-Kattan, Mike S. Lee
thumbnail image: Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

•    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
•    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
•    Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
•    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
•    Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

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