Solid-State Properties of Pharmaceutical Materials

Book Details

  • Published: 26 September 2017
  • ISBN: 978-1-118-14530-2
  • Author: Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen
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Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis

  • Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation
  • Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR
  • Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability
  • Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development
  • Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

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