Multitarget Drugs Fight Neurodegeneration

  • ChemPubSoc Europe Logo
  • Author: Angewandte Chemie International Edition
  • Published Date: 20 September 2017
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Multitarget Drugs Fight Neurodegeneration

Common neurodegenerative diseases such as Alzheimer's or Parkinson's disease have no cure, although numerous biochemical targets offer options for drug therapy. Multitarget-directed drugs could be used to fight the complex mechanisms that underlie such diseases.

Javier Egea, Hospital Universitario de la Princesa, Madrid, Spain, José Marco‐Contelles, Laboratorio de Química Médica, Madrid, Spain, Holger Stark, Heinrich-Heine-Universität, Düsseldorf, Germany, and colleagues have synthesized indole derivatives that simultaneously target different enzymes involved in neurotransmitter breakdown and signaling (namely, acetyl/butyrylcholinesterases and monoamine oxidases A/B as well as the histamine H3 receptor H3R).

The team combined various structural motifs to produce antioxidative/neuroprotective drugs that are capable of penetrating the blood–brain barrier. The most promising in vivo candidate, contilisant (pictured), is a potent inhibitor of monoamine oxidases with irreversible binding properties and was able to improve cognitive deficiencies in mice at 1 mg kg–1. This study suggests that the treatment of neurodegenerative diseases could benefit from a multitarget drug-design approach that addresses several elements of a complex disease mechanism simultaneously.


Article Views: 921

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH