Water-Dispersible Organic Nanodots as Bioimaging Probes

  • ChemPubSoc Europe Logo
  • Author: ChemViews Magazine
  • Published Date: 21 December 2017
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Water-Dispersible Organic Nanodots as Bioimaging Probes

Related Societies

Fluorescent materials can be used for the imaging of living cells. The development of heavy-metal-free, water-dispersible, and biocompatible imaging probes is important. Carbon nitride (C3N4) has suitable optical properties for a bioimaging probe, but its biocompatibility and dispersibility in aqueous media need to be enhanced.


Yong Jin Lee, Korea Institute of Radiological and Medical Sciences, Seoul, Sungjin Park and Dong Wook Kim, Inha University, Incheon, Republic of Korea, and colleagues have incorporated short chain polyethylene glycol (PEG) groups onto a carbon nitride network to solve these problems. The team used an N-alkylation of hexaethylene glycolic mesylate with nucleophilic nitrogen atoms on oxidized carbon nitride (OCN, reaction pictured).


The PEGylated OCN (PEG-OCN) is well dispersed in water as nanodots and shows strong photoluminescence in the visible region. The team used cell viability testing to confirm that these heavy-metal-free, organic nanodots are highly biocompatible and non-cytotoxic. In particular, the developed nanodots could provide clear confocal images of a type of mouse cell without weakening cell activity, while displaying bright green emission.


 

Article Views: 394

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH