Detect Breast Cancer Stem Cells in Vivo

  • ChemPubSoc Europe Logo
  • Author: Chemistry – A European Journal
  • Published Date: 26 March 2018
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Detect Breast Cancer Stem Cells in Vivo

Related Societies

Cancer stem cells (CSCs) contribute to the recurrence and metastasis of cancer. The discovery of synthetic binders of CSCs could help with studying the biology of CSCs as well as in developing diagnostic and therapeutic agents targeting CSCs.


Jiyong Lee and colleagues, University of Texas at Dallas, USA, have isolated the synthetic ligand CL-1-19-1 that specifically binds to CSCs over non-CSCs of breast cancer cells. The binder was identified using a high-throughput screening with a one-bead-one-compound (OBOC) combinatorial chemistry library. OBOC libraries have been previously used to isolate ligands that bind specifically to cancer cells over normal cells but not, as in this case, to isolate ligands that bind to a sub-population of the cancer cells such as CSCs.


The ligand showed specific binding to CD24/CD44+/ALDH+ CSC population of the breast cancer cell lines MCF-7 and MDA-MB-231. The CL-1-19-1-bound cell population shows greater capability of tumor initiation and growth in a mouse model of human breast cancer. According to the researchers, their synthetic binder of breast CSCs can be used to advance knowledge of CSCs and to develop novel imaging/diagnostic/therapeutic agents to detect breast CSCs in vivo.


 

Article Views: 764

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH