Rhenium-Centric Reverse Turn Mimics

  • ChemPubSoc Europe Logo
  • Author: Rachel McGlue
  • Published Date: 18 September 2012
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Rhenium-Centric Reverse Turn Mimics

Related Societies

In biological systems, proteins are the primary means of cellular communication. It relies on a defined spatial orientation of amino acids. However, peptides are not good drug candidates due to their poor bioavailability and limited shelf life. Future lead compounds will likely be nonpeptidic structures. Thus, drug development requires an efficient method of conveying the 3D information in peptide pharmacophores into nonpeptidic structures.

Reverse turns are a common motif in biomolecules, providing many defined 3D structures. Their recognition usually only involves the interaction of amino acid side chains with a receptor, making the peptide backbone unnecessary. 


By using a [Re(CO)3]+ center, Jennifer Hickey and Leonard Luyt, University of Western Ontario, Canada, have shown that amino acid sequences can be assembled, reduced, and coordinated on-resin, resulting in Re–ligand reverse-turn mimics. These are structurally distinct from organic molecules due to the variety of geometries and coordination numbers available, potentially providing more chemical entities with an affinity for biological targets.

This method will allow the synthesis of various turn-based peptidomimetics containing a metal scaffold, and aide in the discovery of new drug-like diagnostic and therapeutic radiopharmaceuticals.


Article Views: 1999

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH