DNA Logic Gates for Metal-ion Sensing

  • ChemPubSoc Europe Logo
  • Author: Anne Deveson
  • Published Date: 30 April 2013
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: DNA Logic Gates for Metal-ion Sensing

Related Societies

Elementary logic gates are capable of performing Boolean logic by receiving one or more inputs and producing a single output; they are key components of electronic integrated circuits, such as those found in computers. Because nucleic acids exhibit many advantages that would rival silicon-based computation, the design of addressable DNA logic gates is at the center of significant research efforts to construct biologically relevant computation systems.


Jian-Ding Qiu and his team, Nanchang University, China, have reported on the development of a series of new metal-ion-mediated DNA logic gates (AND, NAND, and NOR) based on electrochemical outputs. These gates rely on the ability of Ag+ ions to specifically interact with cytosine–cytosine mismatches and of Hg+ ions to specifically interact with thymine–thymine mismatches in DNA duplexes, thus forming the inputs into the logic gates. Detection of the output is based on the change in Faradaic current from the attached redox reporter.

It is envisioned that the present strategy can be used to develop a series of electronic logic gates, which will pave the way for the development of multiplexed point-of-care sensing devices for metal ions.


Article Views: 2382

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH