Nicotine – Chemistry of Smoking

  • ChemPubSoc Europe Logo
  • DOI: 10.1002/chemv.201600038
  • Author: ChemViews
  • Published Date: 03 May 2016
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Nicotine – Chemistry of Smoking

Why do we smoke nicotine and do not inject it?

nicotine - Why do we smoke nicotineTobacco mainly contains nicotine as an active substance, as well as a number of other alkaloids and many other compounds.
These include, for example, hydrogen cyanide, benzene, hydrogen cyanide, ammonia, formaldehyde, acrolein, crotonaldehyde, nitrosamines, hydrazine, vinyl chloride, polycyclic aromatic hydrocarbons, nitrogen oxides, cadmium, lead, nickel, chromium, aluminum, free radicals, radioactive polonium-210, and carbon monoxide.

 

Application Forms of Nicotine [1, 2]

Nicotine has unlimited solubility in both water and in oil. Therefore, application differences are caused by resorption reaction rates and are depend on pH.

 

Nicotine Uptake

 

 

e-Cigarettes

 E-cigarette

 

The liquids of e-cigarettes consist of varying proportions of propylene glycol, glycerin, water, flavoring substances, and possibly nicotine. The nicotine intake with a current evaporator of the 2nd generation compared to the cigarette is much slower.


E-cigarettes might be a harm-reduction option compared to smoking a cigarette. However, the e-cigaretteaerosol is not only water vapor as is often claimed. It can also contain heavy metals, ultrafine particles, and carcinogens such as formaldehyde, acetaldehyde, and acroleine. There are more than 3700 flavours available, whose health risks have not been tested, so far. Many of these flavors are food additives, but it is unclear if something safe to swallow is also safe when inhaled.


[1] Sabine Streller, Klaus Roth, The Chemistry of Tobacco, ChemViews Mag. 2014. DOI: 10.1002/chemv.201400096

[2] Neal L. Benowitz, Janne Hukkanen, Peyton Jacob, Nicotine Chemistry, Metabolism, Kinetics and Biomarkers, Handb. Exp. Pharmacol. 2009, 192, 29–60. DOI: 10.1007/978-3-540-69248-5_2

[3] Sara Zorin, Frederik Kuylenstierna, Hans Thulin, In Vitro Test of Nicotine's Permeability through Human Skin. Risk Evaluation and Safety Aspects, Ann. Occup. Hyg. 1999, 43(6), 405–413. DOI: 10.1093/annhyg/43.6.405

 

Article Views: 4273

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH