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5 Comments

$result.creatorName wrote:

Comment

Aren't the marriage and divorce rates declines simply a function of an aging population?

Thu Oct 13 19:24:45 UTC 2011

Jess Tauber wrote:

Pascal and Metal Means

I've found a relation between Pascal triangle analogues and the so-called 'metal means'. What this portends for our understanding of the periodic relation remains to be explored. At least my muse hasn't left me entirely. Sometime I worry, esp. in dry periods. The monsoons are returning at last. See: http://en.wikipedia.org/wiki/Silver_ratio and the discussion page whose link you can click at the top of the main page- my addition appears at the very bottom of the discussion page.

Thu Oct 13 11:43:31 UTC 2011

$result.creatorName wrote:

At last, someone comes up with the "right" anewsr!

At last, someone comes up with the "right" anewsr!

Thu Oct 13 07:11:11 UTC 2011

$result.creatorName wrote:

Ah, i see. Well that's not too tircky at all!"

Ah, i see. Well that's not too tircky at all!"

Thu Oct 13 06:01:33 UTC 2011

A.M. El-Tawil wrote:

Cyclo‐oxygenase 2 inhibitors and the risk of anastomotic leakage after fast‐track colonic surgery - Your View

Sir,

I read this article with interest. Would like to raise the following points for discussion.

Matrix metalloproteinases (MMPs) are members of the family of zinc (Zn) - and calcium-dependent endopeptidases. The MMP family consists of 25 enzymes, which are classified into eight distinct groups according to their structures. Five of them are secreted types and three of them are membrane-type MMPs. [1] MMPs are produced by various cell types in response to inflammation or tumour progression. MMP-2 is constitutively produced by numerous cell types, whereas MMP-9 is produced by inflammatory cells such as macrophages, neutrophils and epithelial cells of the respiratory tract. MMPs that are produced by inflammatory cells appear to be responsible for microvascular permeability leading to edema and cell transmigration. [2] This means that inflammation is an integral part of the healing process [3] By the intake of non-steroidal anti-inflammatory agent postoperatively, the acute inflammatory response and onset of fibroblast proliferation would likely to be delayed and the anastomotic tensile strength would accordingly be reduced [4] and the anastomotic leakage would then be the outcome.

A.M. El-Tawil
Department of Surgery
University Hospital Birmingham
atawil20052003@yahoo.co.uk

References:

1. Woessner FJ. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-54.

2. Liotta L, Steetler-Stevenson W. Metalloproteinases and cancer invasion. Semin Cancer Biol 1990;1:99-106.

3. Rushfeldt CF, Sveinbjørnsson B, Søreide K, Vonen B. Risk of anastomotic leakage with use of NSAIDs after gastrointestinal surgery. Int J Colorectal Dis. 2011 Aug 11. [Epub ahead of print]

4. De Sousa JB, Soares EG, Aprilli F. Effects of diclofenac sodium on intestinal anastomotic healing. Experimental study on the small intestine of rabbits. Dis Colon Rectum. 1991 Jul; 34(7):613-7.

Wed Oct 12 18:38:57 UTC 2011

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