Adapt and Analyze

  • Author: David Bradley
  • Published: 26 July 2011
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature Chemistry
thumbnail image: Adapt and Analyze

Medical diagnostics and environmental monitoring will be revolutionized by cheap and portable monitors. Now, US researchers have adapted a glucose monitor to detect non-glucose analytes. The modification uses the enzyme invertase, which is released from a functional-DNA-invertase conjugate in the presence of the analyte. Invertase converts sucrose added to the sample to glucose, which is recorded as a proxy of the analyte concentration.


The researchers have successfully tested the modified device against a toxic metal, a disease marker and an illicit drug. It could be adapted easily for other compounds.


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