Effective siRNA Delivery

  • Author: ChemistryViews
  • Published: 25 April 2012
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of the American Chemical Society/ACS
thumbnail image: Effective siRNA Delivery

Gene silencing via RNA interference (RNAi) has demonstrated great potential for the treatment of diseases by halting the production of target proteins. The major challenge in realizing the potential of RNAi therapies resides in delivering small interfering RNA (siRNA) effectively to the cytoplasm of a target cell.

Joseph M. DeSimone, University of North Carolina, Chapel Hill, NC, USA, and colleagues for the first time polymerize siRNA in hydrogel particles for controlled intracellular delivery. The siRNA cargo was found to be adequately protected by the particles and only released upon reaching the reducing environment of the cytoplasm for effective gene knockdown.


Further investigation into shape, size, and surface decoration of siRNA-conjugated hydrogels should enable efficacious targeted in vivo RNAi therapies.


Article Views: 1784

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH