A Novel Way to Fight Tuberculosis

  • Author: Melania Tesio
  • Published: 20 August 2013
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Nature Medicine/Nature Publishing
thumbnail image: A Novel Way to Fight Tuberculosis

Mycobacterium tuberculosis is a pathogenic microorganism that infects the lungs and causes a severe pulmonary disease known as tuberculosis. Multidrug resistant mycobacterial strains are spread worldwide and they constitute a major health issue in many countries.


Kevin Pethe, Pasteur Institute Korea, Korea, and colleagues discovered Q203 (pictured), an imidazopyridine amide derivative that kills drug-resistant tuberculosis strains through a novel mechanism. Unlike other anti-tubercular agents, the new compound targets the respiratory cytochrome bc1 complex, a coenzyme that provides mycobacteria with the energy necessary to proliferate.
When tested in infected mice, Q203 successfully treated tuberculosis without causing noticeable side effects. No signs of toxicity were observed even when Q203 was administered at high doses for a prolonged period of time. Q203 is, thus, a promising new drug for the treatment of tuberculosis.


  • Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis,
    Kevin Pethe, Pablo Bifani, Jichan Jang, Sunhee Kang, Seijin Park, Sujin Ahn, Jan Jiricek, Juyoung Jung, Hee Kyoung Jeon, Jonathan Cechetto, Thierry Christophe, Honggun Lee, Marie Kempf, Mary Jackson, Anne J Lenaerts, Ha Pham, Victoria Jones, Min Jung Seo, Young Mi Kim, Mooyoung Seo, Jeong Jea Seo, Dongsik Park, Yoonae Ko, Inhee Choi, Ryangyeo Kim, Se Yeon Kim, SeungBin Lim, Seung-Ae Yim, Jiyoun Nam, Hwankyu Kang, Haejin Kwon, Chun-Taek Oh, Yoojin Cho, Yunhee Jang, Junghwan Kim, Adeline Chua, Bee Huat Tan, Mahesh B Nanjundappa, Srinivasa P S Rao, Whitney S Barnes, René Wintjens, John R Walker, Sylvie Alonso, Saeyeon Lee, Jungjun Kim, Soohyun Oh, Taegwon Oh, Ulf Nehrbass, Sung-Jun Han, Zaesung No, Jinhwa Lee, Priscille Brodin, Sang-Nae Cho, Kiyean Nam, Jaeseung Kim,
    Nat. Med. 2013.
    DOI: 10.1038/nm.3262

Article Views: 2317

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH