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Natalia Ortuzar
























5-Year Impact Factor:
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A journal of







Dear Scientist,

ChemMedChem is a leading journal in the field of medicinal chemistry, publishing primary research results in the form of both Full Papers and Communications, as well as key secondary and tertiary contributions such as Reviews, Concepts and Highlights. Articles are published with quality and speed in mind. A decision is typically reached within 19 days of submission, and online publication usually follows receipt of the final version within around 28 days.

To showcase the journal's excellent content, we are giving you free access to ChemMedChem's top 25 most-accessed articles of the last 12 months.

The broad scope of the journal is reflected in the diverse topics covered by the articles: from traditional small molecules and structure–activity relationship studies to peptidomimetics and the application of computational chemistry in drug design. The articles come from a wide range of researchers in all areas of drug discovery and development from around the world—an indication of the journal's global reach and broad scope.

We hope you enjoy browsing the articles and that you will consider submitting your next manuscript to ChemMedChem.

Natalia Ortuzar

Dr. Natalia Ortúzar
Editor-in-Chief
ChemMedChem


25 Most Accessed Articles from ChemMedChem:

Free Helicobacter Connections
Barry Marshall

Free Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis
Lluís Ballell, Robert H. Bates, Rob J. Young, et al.

Free Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
Stefan Peukert, Karen Miller-Moslin

Free Prodrug Strategies in Anticancer Chemotherapy
Felix Kratz, Ivonne A. Müller, Claudia Ryppa, André Warnecke

Free Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase
Zhengying Pan, Heleen Scheerens, Shyr-Jiann Li, et al.

Free Thiadiazole–a Promising Structure in Medicinal Chemistry
Yijing Li, Jingkun Geng, Yang Liu, Shenghui Yu, Guisen Zhao

Free Carboxylic Acid (Bio)Isosteres in Drug Design
Carlo Ballatore, Donna M. Huryn, Amos B. Smith

Free G-Quadruplexes: Targets in Anticancer Drug Design
Tian-miao Ou, Yu-jing Lu, Jia-heng Tan, Zhi-shu Huang, Kwok-Yin Wong, Lian-quan Gu

Free Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
Ruth Brenk, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt

Free Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
Martin Morgenthaler, Eliane Schweizer, Anja Hoffmann-Röder, et al.

Free Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
Daniel Spinks, Leah S. Torrie, Stephen Thompson, et al

Free The 7 TM G-Protein-Coupled Receptor Target Family
Edgar Jacoby, Rochdi Bouhelal, Marc Gerspacher, Klaus Seuwen

Free Drugs for Hepatitis C: Unlocking a New Mechanism of Action
Thomas W. Bell

Free Low-Molecular-Weight CXCR4 Ligands with Variable Spacers
Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, et al.

Free Runaway ROS as a Selective Anticancer Strategy
Elizabeth I. Parkinson, Paul J. Hergenrother

Free Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases
Lars Bärfacker, Alexander Kuhl, Alexander Hillisch, et al.

Free A Novel Aptamer Developed for Breast Cancer Cell Internalization
Kejing Zhang, Kwame Sefah, Lili Tang, Zilong Zhao, Guizhi Zhu, Mao Ye, Weijia Sun, Steve Goodison, Weihong Tan

Free Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics
Jeremy L. Yap, Shilpa Worlikar, Alexander D. MacKerell, Paul Shapiro, Steven Fletcher

Free Discovery of Schaeffer’s Acid Analogues as Lead Structures of Mycobacterium tuberculosis Type II Dehydroquinase Using a Rational Drug Design Approach
Marco F. Schmidt, Oliver Korb, Nigel I. Howard, Marcio V. B. Dias, Tom L. Blundell, Chris Abell

Free Revealing Atropisomer Axial Chirality in Drug Discovery
Steven R. LaPlante, Paul J. Edwards, Lee D. Fader, Araz Jakalian, Oliver Hucke

Free Development of Specific "Drug-Like Property" Rules for Carboxylate-Containing Oral Drug Candidates
Alexander Böcker, Pierre R. Bonneau, Oliver Hucke, Araz Jakalian, Paul J. Edwards

Free The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors
Astrid Spannhoff, Alexander-Thomas Hauser, Ralf Heinke, Wolfgang Sippl, Manfred Jung

Free Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)
L. W. Lawrence Woo, Dharshini Ganeshapillai, Mark P. Thomas, Oliver B. Sutcliffe, Bindu Malini, Mary F. Mahon, Atul Purohit, Barry V. L. Potter

Free From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography
Vani P. Mocharla, Joseph C. Walsh, Henry C. Padgett, Helen Su, Barbara Fueger, Wolfgang A. Weber, Johannes Czernin, Hartmuth C. Kolb

Free Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B–NS3 Protease
M. Zouhir Hammamy, Caroline Haase, Maya Hammami, Rolf Hilgenfeld, Torsten Steinmetzer

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You can find the most accessed articles from some of ChemMedChem's sister journals here:

ChemBioChem Angewandte Chemie IE Chemistry – A European Journal Chemistry – An Asian Journal
 
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