Maurer / Wissenbach / Weber LC-MSn Library of Drugs, Poisons, and Their Metabolites, 2nd Edition

Book Details

  • Published: 10 July 2019
  • ISBN: 978-3-527-34649-3
  • Author: Hans H. Maurer, Dirk K. Wissenbach, Armin A. Weber
thumbnail image: Maurer / Wissenbach / Weber LC-MSn Library of Drugs, Poisons, and Their Metabolites, 2nd Edition

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Optimize your metabolite-based LC-MSn screening and minimize false negative results

The Maurer/Wissenbach/Weber LC-MSn Library of Drugs, Poisons, and Their Metabolites, Second Edition provides a proven metabolite-based LCMSn screening method and MS2 and MS3 spectra of over 2,270 parent compounds and over 3,600 of their metabolites, making it one of the only LC-MSn screening libraries that focuses on metabolite spectra.

The second edition was developed for forensic and clinical research and routine labs to quickly and accurately confirm and identify drugs, poisons, and/or their metabolites. Detection of metabolites increases the sensitivity, detection window and selectivity, allows confirmation of the body passage, and minimizes the risk of false negative LC-MS results possibly caused by ion suppression of the target analyte. Even the risk of false positive results can be reduced considering the metabolite patterns.

LC-MSn Library of Drugs, Poisons, and Their Metabolites, Second Edition includes instrument specific training inserts covering details on:

  • Sample preparation methods
  • Applied chromatographic conditions
  • Applied MS settings


Library Specifications:

Spectra: > 13,000
Structures: 10,787
Toxicologically Relevant Compounds: > 2,270
Metabolites/Artifacts: > 3,600
Endogenous Molecules/Impurities: 90 


Compatibility:

Bruker Toxtyper 2.0
NIST MS Search
Thermo Xcalibur, ToxID

Wissenbach DK, Meyer MR, Remane D, Weber AA, Maurer HH. Development of the first metabolite-based LC-MSn urine drug screening procedure - exemplified for antidepressants. (2011) Anal Bioanal Chem. 400:79-88.

Wissenbach DK, Meyer MR, Remane D, Philipp AA, Weber AA, Maurer HH. Drugs of abuse screening in urine as part of a metabolite-based LC-MSn screening concept. (2011) Anal Bioanal Chem. 400:3481-3489.

 

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