14th EFMC Short Course on Medicinal Chemistry

  • Author/Organiser: European Federation for Medicinal Chemistry (EFMC)
  • Event Website: http://www.efmcshortcourses.org/
  • Event Date: 22 April 2018 to 25 April 2018
  • Event Type: Workshop / Training Course
  • Venue: Castle Oud Poelgeest, Oegstgeest, Leiden, The Netherlands

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The seminar will focus on selected aspects of the discovery and development of peptide therapeutics. The course is intended for scientists working in the field, and the presentations will be given by senior scientists from industry and academia.

Peptides are a gigantic class of bioactive compounds, offering an immense chemical diversity as well as the potential for finding and characterizing new targets and also for developing non-peptidic ‘analogues’. However, the development of peptides into clinically useful pharmaceuticals is full of challenges including their pharmacokinetic properties (short biological half-life, lack of oral bioavailability, difficulties to reach intracellular or intranuclear targets) as well as their conformational flexibility which may cause reduced affinity and selectivity. Recent developments in discovery, manufacturing and formulation, as well as in preclinical and clinical development, has triggered a lasting resurrection of pharmaceutical interest in peptide therapeutics.

Course Organizer

  • Bart DE SPIEGELEER (Ghent University, Belgium)

Local Organizer

  • Henk TIMMERMAN (VU University Amsterdam, The Netherlands)


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