Dihydroxanthane Fluorophores

  • ChemPubSoc Europe Logo
  • Author: Andrei Dragan
  • Published Date: 28 March 2017
  • Source / Publisher: Chemistry - An Asian Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Dihydroxanthane Fluorophores

Synthetic organic dyes are used as ink/paint colorants, antibiotics, laser dyes or food additives. They can also be used as optical "paints" (i.e., fluorophores) in biological contexts, for instance, as contrast agents for imaging. Fluorophores emitting light in the near-infrared (NIR) region provide sensitivity, safety, and deep tissue penetration, but their number is limited.

Jean-Alexandre Richard, Institute of Chemical and Engineering Sciences, Singapore, and colleagues have developed dihydroxanthene (DHX) fluorophores (example pictured) which can serve as chemical biology tools. The team was able to access DHX skeletons bearing an aldehyde at the C4' position and/or a bromine atom at C6' in a one-pot process. Functionalization of the products provided analogues that allowed the team to perform a structure-fluorescence relationship study.

The researchers showed preliminary biological applications by preparing water-soluble DHX dyes and demonstrating that protein labeling was possible. This study streamlines the synthesis of hard-to-access NIR-emitting molecules and provides a novel option for fluorescence imaging.


Article Views: 1553

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH