Total Synthesis of HIV-1 Rev Protein

  • ChemPubSoc Europe Logo
  • Author: ChemViews
  • Published Date: 13 April 2011
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Total Synthesis of HIV-1 Rev Protein

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The HIV-1 Rev protein is responsible for moving viral mRNA out of cell nuclei and creating new infectious particles of the HIV virus in the body. It is a target for the design of anti-HIV drugs, but its tendency to aggregate has made studying it difficult.

Ashraf Brik and colleagues, Ben-Gurion University of the Negev, Israel, have designed a synthetic route to HIV-1 Rev to better enable its study. The team used a modified native chemical ligation strategy with two ligation reactions: Thz–Cys conversion and a desulfurization step. This could be performed as a one-pot synthesis that gave an isolated yield of 15 %. This method to prepare HIV-1 Rev in high quantity and purity without aggregation is also flexible enough to enable the preparation of new synthetic analogues useful to determine its structure–function relationship.

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