The Gift of the GABAA

  • Author: Scott Williams
  • Published Date: 20 May 2011
  • Source / Publisher: ChemMedChem/Wiley-VCH
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: The Gift of the GABA<sub>A</sub>

Related Societies

GABAA receptors are important targets for therapeutic agents that work in the brain: they're involved in cognition, vision, and circadian rhythms, as well as disorders like epilepsy, schizophrenia, and Alzheimer's disease. The commonly prescribed benzodiazepines are an important class of positive GABAA receptor modulators, but come with numerous side effects including sedation, rebound anxiety, and amnesia. However, compounds that bind specific GABAA receptor subtypes and at sites other than the classical benzodiazepine site may yield new drugs with fewer side effects.

Mary Chebib and colleagues, The University of Sydney, Australia, discovered that isoflavones are potent modulators of human recombinant α1β2γ2L receptors. The team's structure-driven design approach led to three lead molecules that are particularly efficacious and thus attractive candidates for further investigating subtype-specific modulation of GABAA receptors for treating neurological disorders.

Article Views: 4139

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH