Metalloenzyme for Water Oxidation

  • ChemPubSoc Europe Logo
  • Author: Andrei Dragan
  • Published Date: 18 February 2018
  • Source / Publisher: Chemistry – An Asian Journal
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Metalloenzyme for Water Oxidation

Water oxidation occurs in nature at the photosystem II, producing electrons and oxygen. Recently, water-oxidizing catalysts have attracted research attention as a key technology for renewable energy production.


A biological water-oxidation catalyst can be prepared by substituting the natural zinc cofactor of the enzyme carbonic anhydrase (CA) with iridium. Min-Chul Kim and Sang-Yup Lee, Yonsei University, Seoul, South Korea, have observed oxygen evolution in a water-oxidation process that was catalyzed by this Ir-substituted CA, abbreviated CA[Ir].


The team performed thermodynamic analyses on the Ir binding to the apo-CA protein (the protein without a co-factor). They found that coordination of Ir to the apoprotein of CA is thermodynamically preferred, which implies that the CA apoprotein is stabilized by Ir binding.


CA[Ir] showed comparable catalytic activity to other Ir-based chemical catalysts. The modified enzyme has a turnover frequency (TOF) of 39.8 min−1 under mild and neutral conditions (30 °C, pH 7). The biological character of CA[Ir] could be beneficial for the development of future eco-friendly, enzymatic catalysts that require good biocompatibility.


 

Article Views: 1519

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH