Insertion of CO2 into C–H Bonds

  • ChemPubSoc Europe Logo
  • Author: Chemistry – A European Journal
  • Published Date: 19 April 2018
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Insertion of CO<sub>2</sub> into C–H Bonds

Related Societies

Sustainable and efficient methods for the use of CO2 in the chemical industry have been highly sought after. However, current strategies for C–C bond-forming reactions with CO2 as a C1 building block are based on prefunctionalized compounds, which inevitably leads to salt waste and limits the sustainability of such methods.

Lukas J. Gooßen, Ruhr-Universität Bochum, Germany, and colleagues have developed a salt-free strategy for CO2 insertion into non-activated C–H bonds. They found that a copper(I) catalyst can enable the reaction of terminal alkynes with CO2 in the presence of a mild base, in this case, an amine. The resulting ammonium salt is less stable than inorganic carboxylates. Therefore, it can be hydrogenated to the primary alcohol with a rhodium/molybdenum catalyst. In this step, only water is released and the regenerated amine can be recovered, making the overall process waste-free.

This work demonstrates the feasibility of salt-free CO2 conversion by means of C–C bond formation. It provides a general strategy for the transformation of any reaction leading to an ammonium carboxylate into a salt-free hydroxymethylation process.


Article Views: 1300

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH