Functionalizing Surfaces with DNA

  • ChemPubSoc Europe Logo
  • Author: Angewandte Chemie International Edition
  • Published Date: 17 July 2018
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Functionalizing Surfaces with DNA

A great deal of knowledge has been accumulated over the past two decades on DNA-functionalized gold nanoparticles. However, it remains a challenge to covalently functionalize many other surfaces, such as metal oxides, transition-metal dichalcogenides, and metal-organic frameworks with DNA.

Jeuwen Liu and colleagues, University of Waterloo, Canada, solved this problem by loading DNA onto gold nanoparticles and then attaching the particles to a variety of materials. A high density of DNA can be loaded on gold nanoparticles, resulting in hybrid spherical nucleic acids (SNAs). Mixing the SNAs with a range of materials, e.g., Fe3O4, TiO2, CoO, and Ag nanoparticles, graphene oxide, the metal-organic framework ZIF‐8, or carbon nanotubes, results in highly stable conjugates (pictured). The stability is caused by the fact that DNA can interact with many different types of surfaces through a range of interactions, including π–π stacking, hydrogen bonding, van der Waals forces, electrostatic interactions, and metal coordination.

The resulting materials are functional because the DNA on the side of the SNAs that is not attached to the surface is available for hybridization. The work broadens the scope of DNA-functionalized materials and could allow for new applications, e.g., in biosensor development, drug delivery, and directed materials assembly.


Article Views: 1076

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH