Antimicrobial Peptides Produced by Bacteria within Mosquitoes

  • ChemPubSoc Europe Logo
  • Author: ChemBioChem
  • Published Date: 02 August 2018
  • Source / Publisher: ChemBioChem/Wiley-VCH
thumbnail image: Antimicrobial Peptides Produced by Bacteria within Mosquitoes

Related Societies

Research on the microbiomes of insects, i.e., the microorganisms living within insects, has led to the discoveries of new natural products with interesting bioactivities and potential implications for ecology. Jon Clardy, Harvard Medical School, Boston, MA, USA, Emily R. Derbyshire, Duke University, Durham, NC, USA, and colleagues have explored the microbiome of the Anopheles mosquito. Anopheles mosquitoes transmit the Plasmodium parasite, the infectious agent that causes malaria. The microbiome can influence the Plasmodium parasite by mechanisms that are not yet fully understood.


The team analyzed the midgut and salivary glands of the mosquitoes using gene sequencing and found Serratia bacteria. They are known as natural product producers. The team used mass spectrometry (MS) to analyze extracts of Serratia cultures and discovered a range of novel lipodepsipeptides in the bacteria's metabolites (example pictured). These compounds are named stephensiolides A–K after the Anopheles stephensi mosquitoes from which the bacteria were isolated.


The discovered peptides have antimicrobial activity against gram-positive bacteria and blood-stage malaria parasites. According to the researchers, this could explain the overwhelming presence of Gram‐negative bacteria over Gram‐positive bacteria within A. stephensi. The peptides also improve the bacteria's mobility, which might strengthen the bacteria's ability to populate Anopheles mosquitoes. The results encourage future efforts towards understanding and exploiting the chemical ecology of mosquitoes to control diseases.


 

 

Article Views: 705

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH