Nanohybrids for Anticancer Photodynamic Therapy

  • ChemPubSoc Europe Logo
  • Author: Chemistry – A European Journal
  • Published Date: 28 August 2018
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Nanohybrids for Anticancer Photodynamic Therapy

Related Societies

Indocyanine green (ICG) is an effective near-infrared (NIR) light absorber for photodynamic therapy (PDT). PDT can be used to treat a range of diseases, including skin conditions and some cancers. ICG has been approved by the Food and Drug Administration (FDA) in the United States in 1959. However, the use of ICG has been hampered by its fast degradation and poor photostability in water.


Xing-Can Shen, Guangxi Normal University, China, and colleagues have stabilized ICG by binding it to the surface of single-walled carbon nanohorns (SWNHs, pictured). SWNHs were added to an aqueous solution of ICG and the mixture was sonicated for 3 h. The resulting SWNH‐ICG nanohybrids were isolated using centrifugation. In the product, the dye is bound to the SWNHs through π-π stacking interactions.


The prepared nanohybrids show high solubility and stability in water. The SWNH carriers significantly improve the photostability of ICG. The team attributes this effect to the excellent NIR light absorption capacity of SWNHs, which prevents the adsorbed ICG from being degraded. The nanohybrids show efficient therapeutic effects even under low-power NIR light. When irradiated, they produce heat and reactive oxygen species, which can both kill cancer cells. According to the researchers, SWNH-ICG nanohybrids are promising for the development of a new generation of cancer treatment systems.


 

Article Views: 624

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH