Ferracyclopentenone Complexes

  • ChemPubSoc Europe Logo
  • Author: ChemPlusChem
  • Published Date: 17 December 2019
  • Source / Publisher: ChemPlusChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Ferracyclopentenone Complexes

Related Societies

Diiron species can perform reactions not available to monometallic species. This is due to the cooperative effects of the two iron atoms working together. Half-sandwich organoiron complexes containing the robust cyclopentadienyl ligand have potential applications in medicinal chemistry and in catalysis. However, the classical procedures to obtain this family of compounds have some limitations when it comes to the structures of the other ligands.


Fabio Marchetti, University of Pisa, Italy, and colleagues have developed a synthetic strategy that uses a diiron precursor to create half-sandwich iron complexes with a metallacycle that is unique in organometallic chemistry: an amino-substituted ferracyclopentenone. The metallacycle is synthesized starting from the commercially available Fe2Cp2(CO)4. This compound is converted into diiron μ‐vinyliminium complexes (pictured below on the left), which are then converted to the desired ferracyclopentenone complexes (pictured below on the right) using pyrrolidine as a reducing agent.

 


The reaction is straightforward and works for a range of different substitutents. The obtained compounds show significant cytotoxicity against certain cancer cell lines, in some cases with a reasonable degree of selectivity for cancer cells over non-tumor cells.


 

 

Article Views: 1292

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)published by Wiley-VCH