Self-Healing DNA Origami Nanostructures

  • Author: Angewandte Chemie International Edition
  • Published Date: 17 March 2021
  • Copyright: Wiley-VCH GmbH
thumbnail image: Self-Healing DNA Origami Nanostructures

Nanorulers are DNA origami nanostructures that can be used as brightness standards and distance rulers in optical microscopy. However, they are vulnerable to light and enzymatic damage. Self‐repair of such artificial self-assembled molecular machines, like similar structures in nature, could be a useful approach to solve these problems.

Viktorija Glembockyte, Philip Tinnefeld, Ludwig Maximilian University of Munich, Germany, and colleagues have shown that defective DNA origami structures can repair themselves with the help of their self-assembling properties. By weakening key interactions between different strands in the DNA nanostructure, they can undergo a constant exchange with a pool of intact building blocks. This self‐regeneration can be driven by thermal energy or by the occurrence of damage. Using this approach, the overall lifetime of the devices can be drastically increased.

This dynamic self-repair could have advantages over existing static approaches to stabilize DNA nanostructures, such as encapsulation. This work represents a step towards the complex repair mechanisms of living organisms, where continuous regeneration is standard.



Article Views: 2933

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH