Continuous-Flow Dehydrogenative Coupling of Phenols and Naphthols

  • Author: ChemistrySelect
  • Published Date: 24 November 2021
  • Copyright: Wiley-VCH GmbH
thumbnail image: Continuous-Flow Dehydrogenative Coupling of Phenols and Naphthols

Related Societies

The production of fine chemicals using continuous-flow methods is useful for green and sustainable chemistry. Catalytic reactions over packed-bed reactors reduce the formation of chemical wastes and avoid catalyst separation procedures. They can also enable direct connections of two or more reactions in sequence.


Shun-ya Onozawa, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, Shū Kobayashi, AIST and The University of Tokyo, Japan, and colleagues have developed an efficient continuous-flow synthetic method for biphenols and binaphthols using alumina-supported ruthenium hydroxide as a heterogeneous catalyst (pictured below). Oxygen was used as the sole oxidant for dehydrogenative coupling reactions of phenols and naphthols, yielding only water as a byproduct.

 


The team found that the Ru catalyst could be recycled at least three times by a simple online washing/activation procedure without depackaging the catalyst cartridge. They also showed that the approach can be used in a continuous-flow oxidation/hydrogenation sequence.


 

 

Article Views: 744

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH