Glowing Glucose Complexes Reveal Cancers’ ‘Sweet Tooth’

  • Author: Victoria Barton
  • Published Date: 10 July 2011
  • Source / Publisher: Chemistry - A European Journal/Wiley-VCH
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Glowing Glucose Complexes Reveal Cancers’ ‘Sweet Tooth’

Related Societies

Malignant cell growth is strongly dependent on increased glucose uptake and metabolism, which is possibly due to the higher expression levels of glucose transporters (GLUTs) in cancer cells compared to normal cells.

Kenneth Kam-Wing Lo, City University of Hong Kong, and colleagues describe the synthesis and biological evaluation of three luminescent rhenium(I) polypyridine complexes modified with an α-D-glucose moiety. The much higher cellular uptake of the glucose complexes (the glowing grapes in the picture) by cancer cells (devil) compared to normal cells (angels), indicated that the uptake of these glucose complexes is mediated by GLUTs. A range of experimental techniques were also used to investigate their photophysics, biomolecular binding, bacterial staining, and cellular-uptake properties.

These complexes can serve as new imaging reagents and glucose-uptake indicators for mammalian cells.


Article Views: 4037

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH