Straightforward Synthesis of Nitriles

  • Author: ChemViews
  • Published Date: 24 July 2011
  • Source / Publisher: European Journal of Organic Chemistry/Wiley-VCH
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Straightforward Synthesis of Nitriles

Related Societies

Nitrile functionalities are one of the key structural motifs in organic and industrial chemistry. They allow entry to the synthesis of pharmaceuticals, agrochemicals, and polymers.

Stephan Enthaler, Technische Universit├Ąt Berlin, Germany, investigated the straightforward iron-catalyzed dehydration of a variety of aromatic and alkyl amides to the corresponding nitriles by using N-methyl-N-(tri-methylsilyl)trifluoroacetamide (MSTFA) as the dehydration reagent. After optimization of the reaction conditions, excellent catalytic activities and selectivities were feasible.


Article Views: 4501

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH