Straightforward Synthesis of Nitriles

  • Author: ChemViews
  • Published Date: 24 July 2011
  • Source / Publisher: European Journal of Organic Chemistry/Wiley-VCH
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Nitrile functionalities are one of the key structural motifs in organic and industrial chemistry. They allow entry to the synthesis of pharmaceuticals, agrochemicals, and polymers.

Stephan Enthaler, Technische Universit├Ąt Berlin, Germany, investigated the straightforward iron-catalyzed dehydration of a variety of aromatic and alkyl amides to the corresponding nitriles by using N-methyl-N-(tri-methylsilyl)trifluoroacetamide (MSTFA) as the dehydration reagent. After optimization of the reaction conditions, excellent catalytic activities and selectivities were feasible.

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Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH