Sensitive and Selective Dopamine Sensor

  • ChemPubSoc Europe Logo
  • Author: ChemPlusChem
  • Published Date: 28 December 2011
  • Source / Publisher: ChemPlusChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Sensitive and Selective Dopamine Sensor

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Graphene has become widely used in the field of analytical electrochemistry. This is because a graphene-modified interface can provide a large electrochemically active area and leads to high detection sensitivity.

As a result of a collaborative study between researchers at the Chinese Academy of Sciences and King Abdulaziz University, Jeddah, Saudi Arabia, Xuping Sun and his team have fabricated a graphene-on-gold electrode that can be used for detecting dopamine (DA). The approach exploits interactions between graphene and DNA bases using thiolated single-stranded DNA as a linker and π-π stacking interactions (see figure). Because graphene can absorb the carbon-based rings of DA in a stable manner and retain the excellent conductivity of the gold electrode, the sensor exhibits high sensitivity and selectivity in the presence of ascorbic acid and has a detection limit for DA of 0.8 nm.

This is a new approach for using graphene-on-gold substrates as sensors where the electrode fabrication process is complete within 30 minutes.

Image: © Wiley-VCH

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