Fighting Biofilms

  • Author: ChemViews
  • Published Date: 06 January 2012
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Fighting Biofilms

Related Societies

Bacteria growing in biofilms are often in metabolic and physiological states that do not respond well to antibiotics, and thus, are major contributors to chronic diseases. Biofilm inhibitors, therefore, have the potential to be used alone or as adjuvants to conventional antibiotic therapies.

The protein kinase C inhibitor, palmitoyl-dl-carnitine (pdlc), is a micromolar-range inhibitor of biofilm formation, and affects multiple processes shown to be of importance to biofilm development of Pseudomonas aeruginosaP. aeruginosa is a prominent cause of chronic infections in individuals with cystic fibrosis (CF) as well as in immunecompromised patients and burn victims.
Lori L. Burrows and colleagues, McMaster University, Hamilton, ON, Canada, show that pdlc has potential utility as an antibiotic adjuvant, not only by blocking aminoglycoside-mediated biofilm stimulation but also by preventing bacteria from entering a biofilm state that is tolerant of conventional antimicrobials. Since the pdlc blocks biofilm formation by a combination of mechanisms, resistance to its effects is less likely to arise.

Article Views: 2931

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH