Nobel Prize in Physiology or Medicine 2012

  • Author: ChemistryViews
  • Published Date: 08 October 2012
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  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
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The Nobel Prize in Physiology or Medicine 2012 has been awarded with one half to Sir John B. Gurdon, Gurdon Institute, Cambridge, UK, and the other half to Shinya Yamanaka, Kyoto University, Kyoto, Japan, and Gladstone Institute, San Francisco, CA, USA, "for the discovery that mature cells can be reprogrammed to become pluripotent".

John B. Gurdon, born 1933 in Dippenhall, UK, studied zoology at Christ Church, Oxford, UK. For his PhD he studied nuclear transplantation in the frog Xenopus with Michael Fischberg at Oxford. After postdoctoral work at Caltech, USAm, he worked at the Department of Zoology, University of Oxford, UK, from 1962 to 1971 and at the MRC Laboratory of Molecular Biology, Cambridge, UK, from 1971 to 1983, before he joined the Department of Zoology, University of Cambridge in 1983.
In 1989, he was a founding member of the Wellcome/CRC Institute for Cell Biology and Cancer (later Wellcome/CR, UK) in Cambridge, and was its Chair until 2001. He was a member of the Nuffield Council on Bioethics from 1991 to 1995, and Master of Magdalene College, Cambridge from 1995 to 2002.

John B. Gurdon is best known for his pioneering research in nuclear transplantation and cloning.

Shinya Yamanaka, born 1962 in Higashiōsaka, Japan, received his M.D. at Kobe University, in 1987 and his Ph.D. at Osaka City University Graduate School in 1993, both in Japan.
From 1987 to 1989, Yamanaka was a Resident in orthopedic surgery at the National Osaka Hospital, Japan, and from 1993 to 1995 a Postdoctoral Fellow at the Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, USA. From 1995 to 1996, he was a staff research investigator at the UCSF-affililated Gladstone Institute of Cardiovascular Disease, from 1996 to 1999 an assistant professor at Osaka City University Medical School, from 1999 to 2003 an associate professor at the Nara Institute of Science and Technology, form 2003 to 2005 a professor at the Nara Institute of Science and Technology, and from 2004 to 2010, Shinya Yamanaka was a professor at the Institute for Frontier Medical Sciences. Currently he is the director and a professor at the Center for iPS Cell Research and Application at Kyoto University, Japan.

Shinya Yamanaka and his team were able to generate Induced Pluripotent Stem Cells from mouse and human adult fibroblasts.


John B. Gurdon


Journal articles

Shinya Yamanaka

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