Assembling Gold Nanorods Using DNA

  • Author: Melania Tesio
  • Published Date: 01 November 2012
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Assembling Gold Nanorods Using DNA

Gold nanorods, nanoparticles with a rod-like shape, transform near-infrared (NIR) light into heat. This conversion has potential medical applications as it can be used to induce the release of drugs loaded onto nanoparticles. However, the bio-physicochemical features of therapeutic NIR-responsive nanorods can be altered by the multi-step strategies currently employed to assemble them.


A new approach developed by Zeyu Xiao, Harvard Medical School, USA, and colleagues overcomes these limitations. The scientists loaded two complementary DNA strands with the drug doxorubicin, captured gold nanorods to one filament and conjugated the second one with ligands targeting cancer cells. Since complementary DNA strands can pair together, the hybridization of the two filaments into a double helix lead to one-step self-assembly of gold nanorods carrying doxorubicin. When delivered to tumor bearing mice, these nanoparticles inhibited cancer’s growth. In fact, they converted NIR light into heat which denaturated the DNA double helix, thereby triggering doxorubicin’s release.


Article Views: 4411

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH