Staging an Emergency Evacuation

  • ChemPubSoc Europe Logo
  • Author: Meghan Campbell
  • Published Date: 01 February 2014
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Quorum sensing is an important form of cell–cell communication for bacteria. By disrupting this process through the use of N-acylated L-homoserine lactones (AHLs), the natural substrate of the LuxR receptor, the formation of harmful biofilms can be avoided.

New information about bacterial resistance to small-molecule derivatives of AHLs from Helen E. Blackwell and colleagues, University of Wisconsin-Madison, Madison, WI, USA, reveals that an efflux pump known as MexAB-OprM can export derivatives of AHL from the interior of the bacteria, which allows a biofilm to develop. When MexAB-OprM is deleted, the cells once again become sensitive to the action of AHL. These studies, done in Pseudomonas aeruginosa, a bacterium common in immune-compromised patients, uncover an important mechanism for bacterial antibiotic resistance.

Another quorum-sensing and biofilm inhibitor, 5,6-dimethyl-2-aminobenzimidazole was not sensitive to the presence of the efflux pump and thus, represents an important lead for future development of quorum-sensing modulators and to fight the growth of biofilms.

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