Amine Methylation Made Easy

  • ChemPubSoc Europe Logo
  • Author: Hayley Charville
  • Published Date: 06 June 2014
  • Source / Publisher: Chemistry a European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Amine Methylation Made Easy

Related Societies

Methyl-substituted amines are widely used for the synthesis of pharmaceuticals, agrochemicals, and dyes. The methods that are commonly used to methylate amines, both in industry and on a laboratory scale, suffer from several drawbacks, including the use of toxic reagents and the generation of stoichiometric amounts of (in)organic salts. Therefore, the development of more environmentally acceptable processes for this transformation is highly desirable.

Matthias Beller, Universität Rostock, Germany, and co-workers have developed a general catalytic method for amine methylation by using formic acid under mild reaction conditions. Under Pt-catalyzed conditions, with formic acid as the C1 building block and silanes as reducing agents, a broad range of aromatic and aliphatic, both primary and secondary, amines can be converted into the corresponding tertiary amines in good to excellent yields.
Beller

The use of this catalytic protocol for the preparation of five current drug molecules and two [N-13C]-labelled drugs has also been demonstrated.


Article Views: 4828

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

1 Comments

Hemanth Kumar wrote:

Reaction Mechanism

Dear All, Can i get brief note of mechanism of this reaction..?? Thank You

Tue Jun 10 15:21:54 UTC 2014

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH