Targeted Drug Delivery with Micelles

  • ChemPubSoc Europe Logo
  • Author: Richard Threlfall
  • Published Date: 19 October 2014
  • Source / Publisher: Asian Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Targeted Drug Delivery with Micelles

To achieve enhanced therapeutic efficacy and reduced side effects during cancer treatment, much effort has been dedicated to the development of intracellular, reduction-responsive, polymeric micelles that can release loaded drugs in response to reductive glutathione in certain cancer cells.


Yanli Zhao and colleagues, Nanyang Technological University, Singapore, reported a simple and versatile approach to fabricate reduction-responsive, shell-sheddable, copolymer micelles for targeted anticancer drug delivery. The copolymer was prepared with controlled molecular weight and integrated functionalities using a double-headed initiator consisting of a disulfide linkage and a folic acid targeting unit. The micelles were then formed and loaded with the anticancer drug doxorubicin by self-assembly.


After uptake into the cytoplasm of HeLa cells, the drug load was released by reduction of the micelles by glutathione, and cell growth was consequently inhibited. The micelles have several advantages, including easy synthesis, high stability, and reduction-triggered rapid drug release, which demonstrate their effectiveness as drug delivery vehicles in cancer treatment.


 

Article Views: 4333

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH