Application of Classical Resolution for Separation of DL-Serine

  • Author: Elmar Zimmermann
  • Published Date: 14 May 2010
  • Source / Publisher: Chem. Eng. Technol./Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Application of Classical Resolution for Separation of <I>DL</I>-Serine

Supporting Information

Many separation techniques have been developed for the production of pure enantiomers from racemic chiral compound-forming substances. On an industrial scale this separation problem is solved mostly by classical resolution via diastereomeric salt formation.

In their recent work, Andreas Seidel-Morgenstern and colleagues, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany, investigate the separation of DL-serine via diastereomeric salt formation. For separation of DL-serine, the resolving agent 2,3-dibenzoyl-D-tartaric acid was proposed. The binary melting point phase diagram and the ternary solubility phase diagrams determined are shown and discussed together with the results. The application of the resolving agent 2,3-dibenzoyl-D-tartaric acid for the resolution of DL-serine was successful as both diastereomeric salts show perfect crystalline behavior.

Article Views: 4924

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH