Nickel-Catalyzed Cross-Coupling Reactions

  • Author: Angew. Chem. Int. Ed.
  • Published Date: 14 May 2010
  • Source / Publisher: Angew. Chem. Int. Ed./Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Nickel-Catalyzed Cross-Coupling Reactions

Supporting Information

Scientists in China have described the Kumada-Tamao-Corriu reaction of phenolic salts with various aryl Grignard reagents using a nickel catalyst. The fact that phenols, in place of aryl halides, can be used directly in cross-coupling chemistry is a significant finding.

Zhang-Jie Shi and co-workers have used this method to prepared biaryl scaffolds, which are important in material chemistry and the construction of natural products. Extra steps of group transfer and the generation of organic wastes were avoided by a direct transformation from the magnesium phenolate itself. Preliminary studies were conducted to understand the reaction mechanism.

Article Views: 4538

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH