Nickel-Catalyzed Cross-Coupling Reactions

  • ChemPubSoc Europe Logo
  • Author: Angew. Chem. Int. Ed.
  • Published Date: 14 May 2010
  • Source / Publisher: Angew. Chem. Int. Ed./Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Nickel-Catalyzed Cross-Coupling Reactions

Supporting Information

Scientists in China have described the Kumada-Tamao-Corriu reaction of phenolic salts with various aryl Grignard reagents using a nickel catalyst. The fact that phenols, in place of aryl halides, can be used directly in cross-coupling chemistry is a significant finding.


Zhang-Jie Shi and co-workers have used this method to prepared biaryl scaffolds, which are important in material chemistry and the construction of natural products. Extra steps of group transfer and the generation of organic wastes were avoided by a direct transformation from the magnesium phenolate itself. Preliminary studies were conducted to understand the reaction mechanism.


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