Oxidative Heck Reaction Of Fluorinated Olefins

  • ChemPubSoc Europe Logo
  • Author: Veronika Belusa
  • Published Date: 28 June 2015
  • Source / Publisher: European Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Oxidative Heck Reaction Of Fluorinated Olefins

Related Societies

Fluorinated compounds are of great interest to medicinal chemistry, materials sciences and agrochemistry. Conjugated aromatic systems with trifluoromethyl groups such as β-(trifluoromethyl)styrene derivatives have found wide use in organic light-emitting diodes and in other applications of materials chemistry. The synthesis of these compounds is difficult, however.

Zhao-Tie Liu, Shaanix Normal University, Xi’an, China, Jian Lu, Xi’an Modern Chemistry Research Institute, China, and colleagues have developed a facile synthesis of (Z)-β-(trifluoromethyl)styrene derivatives (pictured). Commonly available 2,3,3,3-tetrafluoroprop-1-ene was used as a fluorine source in a palladium-catalyzed oxidative Heck reaction.

A large number of important arylboronic acids can be coupled with fluorinated olefins. This makes the method practical for the streamlined synthesis of functionalized styrenes.


Article Views: 1936

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH