Controlled Drug Release

  • Author: Francesca Rita Novara
  • Published Date: 30 October 2015
  • Source / Publisher: Chemistry – A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Controlled Drug Release

Related Societies

Platinum anticancer drugs (pictured) require a controlled delivery because they can easily be involved in unspecific reactions that reduce their efficiency and are responsible for severe side effects. Yangzhong Liu and colleagues, University of Science and Technology of China, Hefei, have prepared a highly biocompatible conjugate made of hybrid nanoparticles of human serum albumin and calcium phosphate.

This complex is very stable and protects the platinum(IV) prodrug from premature reduction in the extracellular environment. Upon reaching the acidic and hypoxic environment typical of tumor cells, the platinum drug is released in its active form from the conjugate and is able to bind to the target DNA. The researchers have also shown that their hybrid albumin conjugates inhibited the proliferation of various cancer cells more efficiently than cisplatin.


Article Views: 2654

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH