In-line Improvement

  • Author: Rosalyne Cowie
  • Published Date: 25 October 2010
  • Source / Publisher: Chemistry - A European Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: In-line Improvement

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The power of using flow chemistry for multistep, multicomponent coupling processes to develop functional molecules with commercial applications and potential healthcare benefits is rapidly increasing.


Steven Ley and co-workers, Cambridge, United Kingdom, have developed a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, which is a potent δ-opioid receptor agonist developed by AstraZeneca.


The four-step process employs a sequence of flow-based microreactors, with integrated purification employing solid-supported reagents and in-line IR analytical protocols using a newly developed ReactIR flow cell.


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Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH