Marking Biomarkers

  • ChemPubSoc Europe Logo
  • Author: ChemViews
  • Published Date: 20 November 2010
  • Source / Publisher: ChemBioChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
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Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D that produces the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine. LPA is a mitogen and chemoattractant for many cell types. ATX has been implicated in tumour progression and inflammation, and might serve as a biomarker.

Researchers around Dr. Huib Ovaa, The Netherlands Cancer Institute, Amsterdam, describe the development of a fluorescent activity-based probe that covalently binds to the active site of ATX, allowing visualization of active ATX.

The activity-based reporter will be useful for monitoring ATX activity in biological fluids and for inhibitor screening.

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