Next Generation of Dendritic Nanocarriers

  • Author: ChemViews
  • Published Date: 24 December 2010
  • Source / Publisher: Chemistry - An Asian Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Next Generation of Dendritic Nanocarriers

A team of scientist around Holger Stephan, Forschungszentrum Dresden-Rossendorf, Institute of Radiopharmacy, Dresden, Germany, has studied the encapsulation and release of nanometer-sized anionic rhenium cluster complexes in biocompatible maltose-decorated dendrimers. They have shown that sugar-capped POPAM dendrimers are well suited to encapsulate and slowly release nanosized guest molecules, such as the anionic hexanuclear rhenium cluster complexes.
Results obtained from time-resolved laser fluorescence spectroscopy indicate that guest molecules are partially de-solvated during the process of inclusion.

These and other features described by the authors may be utilized for the development of novel drug-delivery
systems. The synthetic pathway conveniently allows the modification of dendrimer surfaces with additional biologically
active molecules, hence offering great potential for using such dendritic nanocontainers for targeting in vivo.

Article Views: 3497

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH