Provoking T-Cells with Nanoparticles

  • Author: ChemistryViews
  • Published: 22 February 2011
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Nature Materials/Nature Publishing Group
thumbnail image: Provoking T-Cells with Nanoparticles

The human body responds to a vaccine or virus in two ways: by producing T-cells, which attack infected cells, and by producing B-cells, which secrete antibodies to target the viruses. Synthetic vaccines generally have a lower T-cell response than live vaccines but are safer overall.

Encasing synthetic vaccines in liposomes could help promote T-cell responses due to the virus-like packaging. Darrell Irvine and co-workers, Massachusetts Institute of Technology, USA, have developed a more stable way of assembling liposome nanoparticles. They have crosslinked the headgroups of adjacent lipid bilayers within multilamellar nanoparticles. The interbilayer-crosslinked nanoparticles encapsulated protein antigens in the core. These could be released in the presence of endolysosomal lipases.

The nanoparticles exhibited good stability and provoked a T-cell response comparable to live vaccines. This makes them a potential delivery system for vaccines against diseases that require a high T-cell response, such as HIV.

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