Primary Amines from Renewable Resources

  • Author:
  • Published: 06 March 2017
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: ACS Sustainable Chemistry & Engineering/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Primary Amines from Renewable Resources

Amino acids are renewable resources for the production of bio-based chemicals. Amines are important reactants in organic chemistry and can be used in the production of, e.g., pharmaceuticals, materials, and surfactants. Existing processes to prepare amines often use high temperatures or give mixtures of products.

Dirk E. De Vos and colleagues, University of Leuven, Belgium, have developed a ruthenium-catalyzed reaction that converts amino acids into primary amines in water (reaction pictured). The team used a Ru/C catalyst with a high surface area, H2 as a reduction agent, and H3PO4 to control the pH of the solution. L-Valine, for example, was converted into isobutylamine with yields of up to 87 %.

The reaction proceeds via hydrogenation of the amino acid to an α-amino alcohol, which loses CO to form the corresponding amine. The CO is, in turn, hydrogenated to give methane, which can be recycled. Reaction temperatures can be as low as 135 °C. According to the researchers, the sustainable process is applicable for the synthesis of a variety of primary amines.


Article Views: 2980

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH