Multi-Compartment Drug Release

  • Author: Lisa-Marie Rauschendorfer
  • Published: 08 July 2017
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Advanced Energy Materials/Wiley-VCH
thumbnail image: Multi-Compartment Drug Release

The foreign body response (FBR) of biological tissue is a highly complex and dynamic process, which begins immediately after an injury. It results in various tissue responses, such as the recruitment of inflammatory cells, the fusion of macrophages (a type of white blood cell) to form so-called foreign body giant cells (FBGCs), and eventually in the encapsulation of the foreign body.

Themis R. Kyriakides, Yale University, New Haven, CT, USA, and colleagues have developed a multi-compartment drug delivery system that is able to deliver different drugs at different time scales which correspond to the dynamic process during FBR. This allows a modulation of the tissue response. The drug eluting constructs were fabricated by simultaneous electrospinning (creates core–shell fibers) and electrospraying (creates spheres).

The fibers with a core-shell structure allow the delivery of a hydrophilic drug (the antibiotic ampicillin) from the core and a hydrophobic drug (the anti-inflammatory drug Bay 11-7082) from the shell. These two-component fibers release their respective drug over different timescales. The fibers form a nonwoven fibrous mat with spheres containing a third drug (the antifibrotic agent pirfenidone).

The use of this hybrid system (pictured) for FBR was demonstrated in vivo. It successfully mitigated the macrophage fusion after one week and the fibrotic encapsulation after four weeks. Morevoer, the constructs are rapidlyand easily fabricated making them ideal candidates for use in systems where the ability to engineer a dynamic host process is desired.


Article Views: 922

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from, please contact us first for permission. more

CONNECT: on Facebook on Twitter on YouTube on LinkedIn Sign up for our free newsletter

A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH