Anti-Inflammatory Shrub

  • Author: David Bradley
  • Published: 01 May 2011
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of Natural Products/ACS Publications
thumbnail image: Anti-Inflammatory Shrub

The shrub Illicium oligandrum is a member of the anise family and is used in folk medicine for rheumatoid arthritis. In their search for the physiologically active components, a team in China has now isolated dimeric prenylated C6–C3 compounds from the stem bark of the shrub. The compounds dubbed illicidiones A, B and C, were characterized by NMR, UV and IR spectroscopy, chemical analyses and single-crystal X-ray crystallography.

In terms of activity, they elicited an anti-inflammatory response in tests based on measuring enzyme inhibition ratios in rat cells. The compounds had only a weak effect compared to ginkgolide B, one of the most potent anti-inflammatory agents used in traditional medicine.

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