Doped Graphene as a Peroxidase Mimic

  • Author: Liam Critchley
  • Published: 15 April 2019
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: ACS Nano/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Doped Graphene as a Peroxidase Mimic

Peroxidases are enzymes that catalyze oxidative reactions by transferring electrons to peroxide species to produce hydroxyl radicals. These hydroxyl species may have important functions in biological systems.


Jinwoo Lee, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea, Moon Il Kim, Gachon University, Seongnam, Republic of Korea, Sang Kyu Kwak, Ulsan National Institute of Science and Technology (UNIST), Republic of Korea, and colleagues have created boron- and nitrogen-doped reduced graphene oxide (rGO) sheets that act in a similar way to peroxidase catalysts. The team synthesized graphene oxide (GO) using a modified Hummer's method and used wet chemical methods to produce the doped rGO. Hydrogen borate and melamine were used to create B-and N-oped rGO structures, respectively. The researchers also reacted melamine with B-doped rGO to create co-doped rGO structures.


The co-doped rGO sheets have a 1,000 times greater catalytic efficiency towards decomposing peroxide molecules than pure rGO. Peroxidase mimics can be used to detect biomarkers in bioassays. NB-doped rGO was used in bioassays for acetylcholine and C-reactive protein, where it showed high selectivity and sensitivity–comparable to, or better than, a natural peroxidase.


 

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