New Type of Zwitterionic Polymer Prevents Biofouling

  • Author: ChemistryViews.org
  • Published: 27 June 2019
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Science Advances/American Association for the Advancement of Science
thumbnail image: New Type of Zwitterionic Polymer Prevents Biofouling

Biofouling is the accumulation of biomolecules and microorganisms on surfaces. This is a problem in a variety of fields, e.g., in medical devices, membrane systems, swimming pools, or sprinkler systems. Anti-fouling surfaces can prevent the attachment of biomolecules. Zwitterionic polymers, for example, can be used as ultralow fouling materials due to their superhydrophilicity. These materials have a shell of water molecules around them, which prevents biomolecules from reaching the surface and attaching to it.


Shaoyi Jiang, University of Washington, Seattle, USA, and colleagues have developed a new type of zwitterionic polymer which acts as an effective anti-fouling material. The team was inspired by trimethylamine N-oxide (TMAO), which is a zwitterionic compound found in saltwater fishes. It has a small distance between the positive and negative charge, which leads to optimal hydration of the surface. The researchers incorporated TMAO into a polymer (PTMAO, pictured). The corresponding monomer was synthesized by oxidizing N,N-dimethylaminopropyl acrylamide and then polymerized to give the desired material in the form of a hydrogel.


The team tested the polymer's protein adsorption properties compared with uncoated polypropylene (PP). For this, they used a solution of fibrinogen, a protein found in blood plasma. They found that PTMAO-coated surfaces achieves ultralow protein adsorption, with a reduction of over 97 % of adsorbed fibrinogen compared with PP. The adhesion of cells on PTMAO is also significantly lower than on uncoated materials. According to the researchers, PTMAO could be a broadly applicable nonfouling material for many applications.


 

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