Five New Meroterpenoids Isolated

  • Author: ChemistryViews.org
  • Published: 02 August 2019
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Organic Letters/ACS Publications
  • Associated Societies: American Chemical Society (ACS), USA
thumbnail image: Five New Meroterpenoids Isolated

Meroterpenoids are a type of natural product that are part terpene and part polyketide. They are chemically diverse and often biologically active.


Bin Wu, Zhejiang University, Hangzhou, China, and colleagues have isolated five new meroterpenoids from a strain of Talaromyces marine fungi. The fungi were extracted with dichloromethane. The extract's components were then separated using column chromatography and high-performance liquid chromatography (HPLC). The team obtained the meroterponoids talaromyolides A–D (A pictured) and talaromytin.


The structures of the new compounds were determined using NMR spectroscopy, mass spectrometry (MS), X-ray crystallography (XRC), and electronic circular dichroism (ECD) spectroscopy. Talaromytin, a heptacyclic product, was found to have two slowly interconverting conformers due to different orientations of its side chain. Talaromyolide A has a 6/6/6/5/5/5 polycyclic skeleton (pictured). Talaromyolide B and C both have a 6/6/6/6/6/6 hexacyclic skeleton and only differ by one substituent. Talaromyolide D contains one four-membered ring. It has potent antiviral activity against pseudorabies virus, a type of herpes virus in pigs. According to the researchers, this could make it an interesting research target.


 

Article Views: 552

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH