Antibody Levels Correlate with Vaccine Efficacy

  • Author: ChemistryViews
  • Published: 24 November 2021
  • Copyright: Wiley-VCH GmbH
thumbnail image: Antibody Levels Correlate with Vaccine Efficacy

Several vaccines against COVID-19 have proven safe and effective in clinical trials. It can be challenging to measure the protection a vaccine provides based on immunological markers. Such a predictor, a "correlate of protection", could be useful in the development and approval of further vaccines and in the fight against emerging virus variants.

Peter B. Gilbert, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA, and colleagues have assessed the levels of neutralizing and binding SARS-CoV-2 antibodies in participants in the phase 3 trial of the Moderna COVID-19 vaccine (mRNA-1273, Spikevax) and determined their correlation with vaccine protection against COVID-19. These markers were measured after the second vaccination and four weeks later. The team confirmed that the higher the antibody level, the greater the protection afforded by the vaccine.

All markers were inversely associated with COVID-19 risk. For any of the studied markers, the estimated COVID-19 risk of the participants was about ten times lower for vaccine recipients with antibodies in the top 10 % of values than in those with a negative or undetectable antibody response. Antibody levels that predict mRNA vaccine efficacy could, thus, be used, e.g., to guide modifications of vaccine regimens when it comes to doses and schedules.

Also of Interest



Article Views: 660

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH